PROSTATIC CYTOPLASMIC ANDROGEN RECEPTOR IN PROSTATIC DISEASE
نویسندگان
چکیده
منابع مشابه
Androgen Receptor Expression in Epithelial and Stromal Cells of Prostatic Carcinoma and Benign Prostatic Hyperplasia
BACKGROUND Prostatic carcinoma (PCa) derives from prostatic epithelial cells. However stromal microenvironment, associated with malignant epithelium, also plays a role in prostatic carcinogenesis. Alterations in prostatic stromal cells contribute to the loss of growth control in epithelial cells that lead to progression of PCa. AIM To analyse the differences between Androgen Receptor (AR) exp...
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Androgen-driven stromal-epithelial interactions play a key role in normal prostate development and function as well as in the progression of common prostatic diseases such as benign prostatic hyperplasia and prostate cancer. However, exactly how, and via which cell type, androgens mediate their effects in the adult prostate remains unclear. This study investigated the role for smooth muscle (SM...
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Endogenous androgen levels of prostatic tissues in patients with benign prostatic hypertrophy (BPH) and untreated prostatic cancer (PC) were determined by radioimmunoassay using sephadex LH-20 column chromatography. By this assay procedure, it was possible to measure tissue androgen levels with only 30 approximately 40 mg weight of tissues. In BPH (n=20) the concentrations of steroids (mean +/-...
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We produced polyclonal antibody against human androgen receptor (hAR) by means of immunizing a rabbit with hAR fusion protein that was expressed in E. coli. In Western blot analysis, this antibody, NH27, recognized two protein bands at the site of 110 kDa and 107 kDa in androgen-independent human prostatic cancer cells (PC-3), transfected with full-length hAR expression plasmid DNA and at the s...
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The most common treatment for metastasizing prostatic cancer during the past 30 years has been orchiectomy combined with estrogen therapy, both of which have an arresting effect on this tumor.10-12 During the last years metabolie interactions during this therapy have been noticed to occur. Increased thromboembolic complications,20 disturbances in liver function and jaundice," 14. 17 changes in ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1984
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1928.75.7_1098